Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti‐aging activity of the <i>Ink4/Arf</i> locus

23 Feb 2009

Abstract excerpt

The proteins encoded by the Ink4/Arf locus, p16Ink4a, p19Arf and p15Ink4b are major tumour suppressors that oppose aberrant mitogenic signals. The expression levels of the locus are progressively increased during aging and genome-wide association studies have linked the locus to a number of aging-associated diseases and frailty in humans. However, direct measurement of the global impact of the Ink4/Arf locus on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to MicroRNA in disease regulation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19239418
DOI: 10.1111/j.1474-9726.2009.00458.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti‐aging activity of the <i>Ink4/Arf</i> locusPMID 19239418Read ↗

Involvement of the INK4a/Arf gene locus in senescence.Semantic proximity Read ↗

<i>Ink4‐Arf</i> locus in cancer and agingSemantic proximity Read ↗

Ink4a/Arf expression is a biomarker of agingSemantic proximity Read ↗

The INK4a/ARF locus in murine tumorigenesis.Semantic proximity Read ↗

INK4a/ARF: a multifunctional tumor suppressor locus.Semantic proximity Read ↗

<i>INK4d</i>-Deficient Mice Are Fertile Despite Testicular AtrophySemantic proximity Read ↗

Expression of <i>p16</i><sup><i>INK4a</i></sup> in peripheral blood T‐cells is a biomarker of human agingSemantic proximity Read ↗

Modeling INK4/ARF tumor suppression in the mouse.Semantic proximity Read ↗

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.Semantic proximity Read ↗

The molecular balancing act of p16(INK4a) in cancer and aging.Semantic proximity Read ↗

<i>INK4</i> locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoformSemantic proximity Read ↗

The Arf/p53 Pathway in Cancer and AgingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.