Article
Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase.
Cancer letters - 13 Mar 2000
Matsui A, Ikeda T, Enomoto K, Nakashima H, Omae K, Watanabe M, Hibi T, Kitajima M
Abstract excerpt
There is increasing evidence that catecholestrogens may contribute to the development of breast cancer. Specifically, inactivation of catecholestrogens may prevent the genesis and arrest the progression of the disease. Catechol-O-methyltransferase (COMT), Glutathione S-transferase (GST) M1 and GSTP1 are responsible for the detoxification of catecholestrogens, and are polymorphic in the human population. In this...
Topics
- Adult
- Breast Neoplasms
- Catechol O-Methyltransferase
- Disease Progression
- Female
- Genotype
- Glutathione S-Transferase pi
- Glutathione Transferase
- Humans
- Isoenzymes
- Middle Aged