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Article

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.

Cancer research - 15 Dec 1997

Lavigne J A, Helzlsouer K J, Huang H Y, Strickland P T, Bell D A, Selmin O, Watson M A, Hoffman S, Comstock G W, Yager J D

Abstract excerpt

Mounting evidence suggests that catechol metabolites of estradiol may contribute to the development of estrogen-induced cancers. O-Methylation, catalyzed by catechol-O-methyltransferase (COMT), inactivates catechol estrogens. COMT is polymorphic in the human population, with 25% of Caucasians being homozygous for a low activity allele of the enzyme (COMT(LL)). We hypothesized that low activity COMT may be a risk...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9407957

Genes

COMT
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.PMID 9407957Read ↗

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Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women.Semantic proximity Read ↗

Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer.Semantic proximity Read ↗

Catechol-O-methyltransferase and breast cancer risk.Semantic proximity Read ↗

Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan.Semantic proximity Read ↗

Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk.Semantic proximity Read ↗

Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York.Semantic proximity Read ↗

Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast cancer.Semantic proximity Read ↗

Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25,627 cases and 34,222 controls.Semantic proximity Read ↗

Polymorphic catechol-O-methyltransferase gene and breast cancer risk.Semantic proximity Read ↗

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