Article
An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.
Cancer research - 15 Dec 1997
Lavigne J A, Helzlsouer K J, Huang H Y, Strickland P T, Bell D A, Selmin O, Watson M A, Hoffman S, Comstock G W, Yager J D
Abstract excerpt
Mounting evidence suggests that catechol metabolites of estradiol may contribute to the development of estrogen-induced cancers. O-Methylation, catalyzed by catechol-O-methyltransferase (COMT), inactivates catechol estrogens. COMT is polymorphic in the human population, with 25% of Caucasians bei...
Topics
- Aged
- Alleles
- Breast Neoplasms
- Case-Control Studies
- Catechol O-Methyltransferase
- DNA
- DNA, Neoplasm
- Female
- Genotype
- Humans
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Risk Factors