Article
Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study.
Chinese journal of cancer - 1 Jul 2010
Wang Qiong, Wang Yuan-Ping, Li Jia-Yuan, Yuan Ping, Yang Fei, Li Hui
Abstract excerpt
BACKGROUND AND OBJECTIVE: Genetic polymorphism Val158Met of catechol-O-methyltransferase (COMT) may contribute to estrogen-induced carcinogenesis of breast cancer. Soy isoflavones possesses chemical structure similar to endogenous estrogen and may promote the carcinogenesis of breast cancer. This study was to investigate the relationship between the polymorphism of COMT, soy isoflavones, and breast cancer in...
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