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Article

Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic study on cancer susceptibility.

International journal of cancer - 20 Jan 2005

Cheng Ting-Chih, Chen Shou-Tung, Huang Chiun-Sheng, Fu Yi-Ping, Yu Jyh-Cherng, Cheng Chun-Wen, Wu Pei-Ei, Shen Chen-Yang

Abstract excerpt

Estrogen has been suggested to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). To examine this hypothesis, we carried out a multigenic case-control study of 469 incident breast cancer patients and 740 healthy controls to define the role of important genes involved in the different metabolic steps that protect against the potentially harmful effects...

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Source

Identifiers

PMID: 15455371
DOI: 10.1002/ijc.20630

Genes

COMT
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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