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Article

Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms.

Cancer research - 15 Jul 2008

Ji Yuan, Olson Janet, Zhang Jianping, Hildebrandt Michelle, Wang Liewei, Ingle James, Fredericksen Zachary, Sellers Thomas, Miller William, Dixon J Michael, Brauch Hiltrud, Eichelbaum Michel, Justenhoven Christina, Hamann Ute, Ko Yon, Brüning Thomas, Chang-Claude Jenny, Wang-Gohrke Shan, Schaid Daniel, Weinshilboum Richard

Abstract excerpt

Catechol O-methyltransferase (COMT)-catalyzed methylation of catecholestrogens has been proposed to play a protective role in estrogen-induced genotoxic carcinogenesis. We have taken a comprehensive approach to test the hypothesis that genetic variation in COMT might influence breast cancer risk. Fifteen COMT single nucleotide polymorphisms (SNPs) selected on the basis of in-depth resequencing of the COMT gene...

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Source

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Identifiers

PMID: 18632656
DOI: 10.1158/0008-5472.CAN-08-0043
PMCID: PMC2518124

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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