Catechol-O-methyltransferase and breast cancer risk.

doi:10.1093/carcin/19.11.1943

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Article

Catechol-O-methyltransferase and breast cancer risk.

Carcinogenesis - 1 Nov 1998

Millikan R C, Pittman G S, Tse C K, Duell E, Newman B, Savitz D, Moorman P G, Boissy R J, Bell D A

Abstract excerpt

Recent studies suggest that a polymorphism in catechol-O-methyltransferase (COMT) is associated with increased risk of breast cancer. Methylation by COMT is the principal pathway for inactivation of catechol estrogens, which are hypothesized to participate in estrogen-induced carcinogenesis. We e...

Topics

Adult
Aged
Body Mass Index
Breast Neoplasms
Case-Control Studies
Catechol O-Methyltransferase
Female
Genotype
Humans
Middle Aged
Risk

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