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Article

Catechol-O-methyltransferase and breast cancer risk.

Carcinogenesis - 1 Nov 1998

Millikan R C, Pittman G S, Tse C K, Duell E, Newman B, Savitz D, Moorman P G, Boissy R J, Bell D A

Abstract excerpt

Recent studies suggest that a polymorphism in catechol-O-methyltransferase (COMT) is associated with increased risk of breast cancer. Methylation by COMT is the principal pathway for inactivation of catechol estrogens, which are hypothesized to participate in estrogen-induced carcinogenesis. We examined the association of COMT genotype and breast cancer risk in a population-based, case-control study of invasive...

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Source

Identifiers

PMID: 9855007
DOI: 10.1093/carcin/19.11.1943

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Catechol-O-methyltransferase and breast cancer risk.PMID 9855007Read ↗

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Polymorphic catechol-O-methyltransferase gene and breast cancer risk.Semantic proximity Read ↗

Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer.Semantic proximity Read ↗

Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan.Semantic proximity Read ↗

Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients.Semantic proximity Read ↗

Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study.Semantic proximity Read ↗

Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase.Semantic proximity Read ↗

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