Article
Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli.
Antimicrobial agents and chemotherapy - 1 Apr 2000
Kern W V, Oethinger M, Jellen-Ritter A S, Levy S B
Abstract excerpt
Mutations in loci other than genes for the target topoisomerases of fluoroquinolones, gyrA and parC, may play a role in the development of fluoroquinolone resistance in Escherichia coli. A series of mutants with increasing resistance to ofloxacin was obtained from an E. coli K-12 strain and five clinical isolates. First-step mutants acquired a gyrA mutation. Second-step mutants reproducibly acquired a phenotype...
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