Article
Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates.
The Journal of antimicrobial chemotherapy - 1 Dec 1999
Tavío M M, Vila J, Ruiz J, Ruiz J, Martín-Sánchez A M, Jiménez de Anta M T
Abstract excerpt
Eighteen quinolone-resistant isolates of Escherichia coli were selected by exposing ten clinical isolates to increasing concentrations of norfloxacin and lomefloxacin. The mutant isolates showed a multiple-antibiotic-resistance phenotype. All of them contained single mutations in gyrA consisting of the substitution of Ser-83-->Leu (n = 14), Val (n = 1) or Ala (n = 1) and the substitution of Asp-87-->Asn (n = 2)....
Topics
- Anti-Infective Agents
- Bacterial Outer Membrane Proteins
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Escherichia coli
- Escherichia coli Infections
- Fluoroquinolones
- Humans
- Lipopolysaccharides
- Microbial Sensitivity Tests
- Mutation