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Article

Bacterial resistance to fluoroquinolones.

Reviews of infectious diseases - 1 Jan 2000

Neu H C

Abstract excerpt

Fluoroquinolones inhibit bacteria by interacting with the A subunit of DNA gyrase. Resistance to older agents such as nalidixic acid was due to mutations in the gyrA gene. Resistance to the new fluoroquinolones (e.g., norfloxacin, enoxacin, ofloxacin, pefloxacin, and ciprofloxacin) as a consequence of spontaneous single-step mutation occurs at a low frequency, less than 10(-9), and generally results in a 300-fold...

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Identifiers

PMID: 3279500
DOI: 10.1093/clinids/10.supplement_1.s57

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