Article
Mechanisms of fluoroquinolone resistance in genetically related strains of Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Dec 1997
Kaatz G W, Seo S M
Abstract excerpt
Fluoroquinolone resistance in Staphylococcus aureus results from amino acid substitutions at particular locations in the DNA gyrase A and B subunits as well as in the topoisomerase IV A subunit and from NorA-mediated efflux. More than one resistance mechanism may be present in a single strain. Fl...
Topics
- Anti-Bacterial Agents
- Base Sequence
- DNA Topoisomerases, Type I
- Drug Resistance, Microbial
- Enoxacin
- Ethidium
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Norfloxacin
- Polymorphism, Restriction Fragment Length
- Reserpine
- Staphylococcus aureus