Article
Mechanisms of quinolone resistance.
Infection - 1 Jan 1994
Wiedemann B, Heisig P
Abstract excerpt
Two mechanisms of resistance to fluoroquinolones are known: (i) alteration of the molecular target of quinolone action-DNA gyrase, and (ii) reduction of the quinolone accumulation. Mutations altering the N-terminus of the gyrase A subunit, especially those around residues Ser83 and Asp87, significantly reduce the susceptibilities towards all quinolones, while alterations of the gyrase B subunit are rarely found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.