Article
Mechanisms of quinolone resistance.
Infection - 1 Jan 1994
Wiedemann B, Heisig P
Abstract excerpt
Two mechanisms of resistance to fluoroquinolones are known: (i) alteration of the molecular target of quinolone action-DNA gyrase, and (ii) reduction of the quinolone accumulation. Mutations altering the N-terminus of the gyrase A subunit, especially those around residues Ser83 and Asp87, significantly reduce the susceptibilities towards all quinolones, while alterations of the gyrase B subunit are rarely found...
Topics
- Anti-Infective Agents
- Bacterial Outer Membrane Proteins
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Fluoroquinolones
- Gram-Negative Bacteria
- Gram-Negative Bacterial Infections
- Gram-Positive Bacteria
- Gram-Positive Bacterial Infections