Article
Staphylococcus aureus mutants isolated via exposure to nonfluorinated quinolones: detection of known and unique mutations.
Antimicrobial agents and chemotherapy - 1 Dec 2001
Roychoudhury S, Twinem T L, Makin K M, Nienaber M A, Li C, Morris T W, Ledoussal B, Catrenich C E
Abstract excerpt
The in vitro development of resistance to the new nonfluorinated quinolones (NFQs; PGE 9262932, PGE 4175997, and PGE 9509924) was investigated in Staphylococcus aureus. At concentrations two times the MIC, step 1 mutants were isolated more frequently with ciprofloxacin and trovafloxacin (9.1 x 10(-8) and 5.7 x 10(-9), respectively) than with the NFQs, gatifloxacin, or clinafloxacin (<5.7 x 10(-10)). Step 2 and...
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