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Article

Mechanism of quinolone resistance in Staphylococcus aureus.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Sept 2000

Tanaka M, Wang T, Onodera Y, Uchida Y, Sato K

Abstract excerpt

The resistance mechanisms to fluoroquinolones in Staphylococcus aureus were clarified by analyzing mutations in the genes encoding target enzymes, and examining the expression of the efflux pump, and determining the inhibitory activities of fluoroquinolones against the altered enzymes. Mutations in the grlA and gyrA genes of 344 clinical strains of S. aureus isolated in 1994 in Japan were identified by...

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PMID: 11810552
DOI: 10.1007/s101560070010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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