Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combination of known and unknown mechanisms confers high-level resistance to fluoroquinolones in Enterococcus faecium.

Journal of medical microbiology - 1 Jun 2006

Oyamada Yoshihiro, Ito Hideaki, Fujimoto Kouichi, Asada Reiko, Niga Toshiyuki, Okamoto Ryoichi, Inoue Matsuhisa, Yamagishi Jun-Ichi

Abstract excerpt

In order to elucidate the mechanisms of fluoroquinolone resistance in Enterococcus faecium, spontaneous mutants isolated from Ent. faecium ATCC 19434 by stepwise selection with sparfloxacin (SPX) or norfloxacin (NOR) and 13 clinical isolates of Ent. faecium were characterized by analysing quinolone-resistance-determining regions (QRDRs) of the gyrA, gyrB, parC and parE genes and examining changes in MICs of SPX...

Topics

Anti-Bacterial Agents
Base Sequence
DNA Gyrase
DNA Topoisomerase IV
DNA, Bacterial
Drug Resistance, Bacterial
Enterococcus faecium
Fluoroquinolones
Genes, Bacterial
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Mutation

Source

Identifiers

PMID: 16687591
DOI: 10.1099/jmm.0.46303-0

Genes

SPX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combination of known and unknown mechanisms confers high-level resistance to fluoroquinolones in Enterococcus faecium.PMID 16687591Read ↗

Alterations in GyrA and ParC associated with fluoroquinolone resistance in Enterococcus faecium.Semantic proximity Read ↗

Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.Semantic proximity Read ↗

Contribution of Type II Topoisomerase Mutations to Fluoroquinolone Resistance in Enterococcus faecium from Japanese Clinical Setting.Semantic proximity Read ↗

High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.Semantic proximity Read ↗

Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli.Semantic proximity Read ↗

Association of alterations in ParC and GyrA proteins with resistance of clinical isolates of Enterococcus faecium to nine different fluoroquinolones.Semantic proximity Read ↗

In vitro selection of fluoroquinolone-resistant Neisseria gonorrhoeae harboring alterations in DNA gyrase and topoisomerase IV.Semantic proximity Read ↗

Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.Semantic proximity Read ↗

Novel mutations in quinolone resistance-determining regions of gyrA, gyrB, parC and parE in Shigella flexneri clinical isolates from eastern Chinese populations between 2001 and 2011.Semantic proximity Read ↗

Novel gyrase mutations and characterization of ciprofloxacin-resistant clinical strains of Enterococcus faecalis isolated in Poland.Semantic proximity Read ↗

Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates.Semantic proximity Read ↗

[Resistance to quinolones and beta-lactams in Salmonella enterica due to mutations in topoisomerase-encoding genes, altered cell permeability and expression of an active efflux system].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.