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Article

In vitro selection of resistance to pradofloxacin and ciprofloxacin in canine uropathogenic Escherichia coli isolates.

Veterinary microbiology - 5 Dec 2014

Liu Xiaoqiang, Lazzaroni Caterina, Aly Sherine A, Thungrat Kamoltip, Boothe Dawn M

Abstract excerpt

This study explored and compared the mechanisms and selective concentration of resistance between a 3rd (pradofloxacin) and 2nd (ciprofloxacin) generation fluoroquinolone. Pradofloxacin- and ciprofloxacin-resistant mutants were selected by stepwise exposure of Escherichia coli (E. coli) to escalating concentrations of pradofloxacin and ciprofloxacin. The sequence of the quinolone resistance determining region...

Topics

Animals
Anti-Bacterial Agents
Ciprofloxacin
DNA Gyrase
DNA Topoisomerases, Type I
Dog Diseases
Dogs
Drug Resistance, Bacterial
Escherichia coli Infections
Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fluoroquinolones

Microbial Sensitivity Tests

Mutation

Urinary Tract Infections

Uropathogenic Escherichia coli

Source

Identifiers

PMID: 25465666
DOI: 10.1016/j.vetmic.2014.10.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25465666-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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