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Article

Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli.

Antimicrobial agents and chemotherapy - 1 Apr 2012

Singh Renu, Swick Michelle C, Ledesma Kimberly R, Yang Zhen, Hu Ming, Zechiedrich Lynn, Tam Vincent H

Abstract excerpt

The emergence of resistance presents a debilitating change in the management of infectious diseases. Currently, the temporal relationship and interplay between various mechanisms of drug resistance are not well understood. A thorough understanding of the resistance development process is needed to facilitate rational design of countermeasure strategies. Using an in vitro hollow-fiber infection model that...

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Identifiers

PMID: 22232279
DOI: 10.1128/AAC.05693-11
PMCID: PMC3318314

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