Article
Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice.
Arthritis and rheumatism - 1 Feb 2000
Haywood M E, Hogarth M B, Slingsby J H, Rose S J, Allen P J, Thompson E M, Maibaum M A, Chandler P, Davies K A, Simpson E, Walport M J, Morley B J
Abstract excerpt
OBJECTIVE: To identify intervals containing systemic lupus erythematosus (SLE) susceptibility alleles in the BXSB strain of mice. METHODS: We analyzed 286 (B10 x [B10 x BXSB]F1) backcross mice for a range of phenotypic traits associated with the development of SLE in BXSB mice. The mice were genotyped using 93 microsatellite markers, and the linkage of these markers to disease was studied by extreme-phenotype and...
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