Article
Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2004
Haywood Michelle E K, Rogers Nicola J, Rose S Jane, Boyle Joseph, McDermott Aileen, Rankin Joanna M, Thiruudaian Vasuky, Lewis Margarita R, Fossati-Jimack Liliane, Izui Shozo, Walport Mark J, Morley Bernard J
Abstract excerpt
To dissect the individual effects of the four non-MHC, autosomal loci (Bxs1 to Bxs4) that contribute to SLE susceptibility in BXSB mice, we generated congenic lines from chromosome 1 on a C57BL/10.Y(BXSB) (B10.Yaa) background for the intervals (values in megabases (Mb)) Bxs1 (46.3-89.2 Mb), Bxs1/4 (20.0-65.9 Mb), Bxs1/2 (64.4-159.0 Mb), and Bxs2/3 (105.4-189.0 Mb). Glomerulonephritis, qualitatively similar to...
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