An autosomal recessive gene that delays expression of lupus in BXSB mice.

Article

An autosomal recessive gene that delays expression of lupus in BXSB mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1991

Kofler R, McConahey P J, Duchosal M A, Balderas R S, Theofilopoulos A N, Dixon F J

Abstract excerpt

We report the generation and serologic, cellular, histologic, and genetic characteristics of a BXSB/MpJScr substrain, termed BXSB/MpJScr-ll/ll, that has lost early-life male lupus disease. Classic genetic analysis suggested that delayed disease expression results from the action of a single autos...

Topics

Animals
DNA, Viral
Disease Models, Animal
Genes, Recessive
Genetic Predisposition to Disease
Life Expectancy
Lupus Erythematosus, Systemic
Male
Mice
Mice, Inbred Strains
Retroviridae

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