Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2005

Xu Zhiwei, Duan Biyan, Croker Byron P, Wakeland Edward K, Morel Laurence

Abstract excerpt

Lupus pathogenesis in the NZM2410 mouse model results from the expression of multiple interacting susceptibility loci. Sle2 on chromosome 4 was significantly linked to glomerulonephritis in a linkage analysis of a NZM2410 x B6 cross. Yet, Sle2 expression alone on a C57BL/6 background did not result in any clinical manifestation, but in an abnormal B cell development, including the accumulation of B-1a cells in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocyte Subsets
Share to Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lupus Nephritis

Share to Lymphocyte Count

Share to Mice, Congenic

Share to Mice, Inbred NZB

Share to Myeloid Cells

Share to Peritoneal Cavity

Source

Identifiers

PMID: 16002692
DOI: 10.4049/jimmunol.175.2.936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci.PMID 16002692Read ↗

Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity.Semantic proximity Read ↗

Susceptibility genes in the pathogenesis of murine lupus.Semantic proximity Read ↗

Genetic Dissection of SLESemantic proximity Read ↗

The NZM2410-derived lupus susceptibility locus Sle2c1 increases Th17 polarization and induces nephritis in fas-deficient mice.Semantic proximity Read ↗

Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.Semantic proximity Read ↗

Functional dissection of systemic lupus erythematosus using congenic mouse strains.Semantic proximity Read ↗

Lupus susceptibility loci in New Zealand mice.Semantic proximity Read ↗

Murine lupus susceptibility locus Sle2 activates DNA-reactive B cells through two sub-loci with distinct phenotypes.Semantic proximity Read ↗

Mechanisms of peritoneal B-1a cells accumulation induced by murine lupus susceptibility locus Sle2.Semantic proximity Read ↗

Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodiesSemantic proximity Read ↗

Genetic interactions between susceptibility loci reveal epistatic pathogenic networks in murine lupus.Semantic proximity Read ↗

Mapping lupus susceptibility genes in the NZM2410 mouse model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.