Article
Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2005
Xu Zhiwei, Duan Biyan, Croker Byron P, Wakeland Edward K, Morel Laurence
Abstract excerpt
Lupus pathogenesis in the NZM2410 mouse model results from the expression of multiple interacting susceptibility loci. Sle2 on chromosome 4 was significantly linked to glomerulonephritis in a linkage analysis of a NZM2410 x B6 cross. Yet, Sle2 expression alone on a C57BL/6 background did not result in any clinical manifestation, but in an abnormal B cell development, including the accumulation of B-1a cells in...
Topics
- Animals
- B-Lymphocyte Subsets
- Cell Differentiation
- Chromosome Mapping
- Female
- Gene Expression Regulation
- Genetic Markers
- Genetic Predisposition to Disease
- Kidney
- Lupus Erythematosus, Systemic
- Lupus Nephritis
- Lymphocyte Count
- Male