Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2007

Haywood Michelle E K, Gabriel Luisa, Rose S Jane, Rogers Nicola J, Izui Shozo, Morley Bernard J

Abstract excerpt

The BXSB strain of recombinant inbred mice develops a spontaneous pathology that closely resembles the human disease systemic lupus erythematosus. Six non-MHC loci, Yaa, Bxs1-4, and Bxs6, have been linked to the development of aspects of the disease while a further locus, Bxs5, may be a BXSB-derived disease suppressor. Disease development is delayed in a substrain of BXSB, BXSB/MpJScr-long-lived (BXSB/ll). We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breeding
Share to Chromosomes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Lupus Erythematosus, Systemic

Share to Mice, Inbred Strains

Share to Quantitative Trait Loci

Share to Recombination, Genetic

Share to Species Specificity

Source

Identifiers

PMID: 17675504
DOI: 10.4049/jimmunol.179.4.2428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BXSB/long-lived is a recombinant inbred strain containing powerful disease suppressor loci.PMID 17675504Read ↗

An autosomal recessive gene that delays expression of lupus in BXSB mice.Semantic proximity Read ↗

Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease.Semantic proximity Read ↗

Lupus susceptibility loci map within regions of BXSB derived from the SB/Le parental strain.Semantic proximity Read ↗

Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice.Semantic proximity Read ↗

Multiple lupus susceptibility loci map to chromosome 1 in BXSB mice.Semantic proximity Read ↗

The Bxs6 locus of BXSB mice is sufficient for high-level expression of gp70 and the production of gp70 immune complexes.Semantic proximity Read ↗

Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain.Semantic proximity Read ↗

Genetic control of spontaneous arthritis in a four-way advanced intercross line.Semantic proximity Read ↗

A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice.Semantic proximity Read ↗

Systemic lupus erythematosus--recent clues from congenic strains.Semantic proximity Read ↗

Genetic Segregation of Spontaneous Erosive Arthritis and Generalized Autoimmune Disease in the BXD2 Recombinant Inbred Strain of MiceSemantic proximity Read ↗

Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.