Article
Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.
Zhongguo yao li xue bao = Acta pharmacologica Sinica - 1 Jul 1999
Chen S Q, Wedlund P J
Abstract excerpt
AIM: To study the correlation between CYP2D6 genotype and its phenotype. METHODS: CYP2D6 genotyping was made by detecting CYP2D6*3, *4, *6, and *7 alleles with an allele-specific polymerase chain reaction procedure. RESULTS: The CYP2D6 genotypes were well correlated with its phenotypes in all 125 extensive metabolizers and in 43 poor metabolizers. Extensive metabolizers had at least one wildtype CYP2D6 gene and...
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