Article
Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation.
American journal of physiology. Gastrointestinal and liver physiology - 1 Feb 2000
de Jong T A, Skinner S A, Malcontenti-Wilson C, Vogiagis D, Bailey M, van Driel I R, O'Brien P E
Abstract excerpt
Nonsteroidal anti-inflammatory drug (NSAID) use reduces the risk of colorectal cancer by 40-50%. Previous studies suggest that effective inhibition of colorectal cancer by NSAIDs may be dependent on the presence or absence of a K-ras mutation. This study was aimed at determining the relationship between inhibition of colorectal cancer by sulindac and sulindac sulfone and the presence of activating K-ras mutations...
Topics
- 1,2-Dimethylhydrazine
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Antineoplastic Agents
- Carcinogens
- Codon
- Colonic Neoplasms
- Female
- Genes, ras
- Male
- Mutation