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Article

Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.

Carcinogenesis - 1 Nov 2009

Itano Osamu, Yang Kan, Fan Kunhua, Kurihara Naoto, Shinozaki Hiroharu, Abe Sadanori, Jin Bo, Gravaghi Claudia, Edelmann Winfried, Augenlicht Leonard, Kopelovich Levy, Kucherlapati Raju, Lamprecht Sergio, Lipkin Martin

Abstract excerpt

We have previously reported that sulindac, a non-steroidal anti-inflammatory drug, inhibited tumor formation in the small intestine but increased tumors in the colon of Apc(Min/+) mice, a model of human familial adenomatous polyposis. To further explore intestinal regional responses, we studied effects of sulindac on additional gene-targeted mouse models of human intestinal tumorigenesis; these were (i)...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anti-Inflammatory Agents, Non-Steroidal

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Source

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Identifiers

PMID: 19755659
DOI: 10.1093/carcin/bgp200
PMCID: PMC2783002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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