The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: tumour development in female SWR mice does not require a K-ras mutational event.

doi:10.1093/carcin/20.3.509

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Article

The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: tumour development in female SWR mice does not require a K-ras mutational event.

Carcinogenesis - 1 Mar 1999

Jackson P E, Cooper D P, O'Connor P J, Povey A C

Abstract excerpt

In this study we have investigated the relationship between the dose of 1,2-dimethylhydrazine (DMH) and the yield (and location) of tumours in a mouse strain susceptible to colon tumour induction. Female SWR mice were injected with 6.8 mg/kg DMH i.p. once a week for 1, 5, 10 and 20 weeks and the...

Topics

1,2-Dimethylhydrazine
Adenocarcinoma
Animals
Base Sequence
Carcinogens
Colonic Neoplasms
DNA Primers
Dose-Response Relationship, Drug
Female
Genes, ras
Mice
Mutation

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