Article
Relationship between APC genotype, polyp distribution, and oral sulindac treatment in the colon and rectum of patients with familial adenomatous polyposis.
Diseases of the colon and rectum - 1 Aug 2001
Guldenschuh I, Hurlimann R, Muller A, Ammann R, Mullhaupt B, Dobbie Z, Zala G F, Flury R, Seelentag W, Roth J, Meyenberger C, Fried M, Hoppeler T, Spigelman A D, Scott R J
Abstract excerpt
PURPOSE: Familial adenomatous polyposis is an inherited colorectal cancer syndrome characterized by the presence of multiple adenomatous colorectal polyps. Molecular studies have revealed that germline mutations in the APC gene are the underlying cause of the disease. The nonsteroidal anti-inflammatory agent sulindac has been shown to reduce the number of colorectal adenomas. Most sulindac trials in the large...
Topics
- Adenomatous Polyposis Coli
- Administration, Oral
- Adolescent
- Adult
- Aged
- Cell Transformation, Neoplastic
- Colonoscopy
- Female
- Genes, APC
- Genotype
- Germ-Line Mutation
- Humans
- Male