Article
Diallyl sulfide enhances azoxymethane-induced preneoplasia in Fischer 344 rat colon.
Chemico-biological interactions - 1 Feb 2000
Delker D A, Papanikolaou A, Suhr Y J, Rosenberg D W
Abstract excerpt
Azoxymethane (AOM) is an indirect-acting colon carcinogen that produces a high incidence of precancerous lesions, referred to as aberrant crypt foci (ACF), in rats. This study was undertaken to determine whether high dose gavage administration of the cytochrome P-450 2E1 (CYP2E1) inhibitor and ch...
Topics
- Allyl Compounds
- Animals
- Anticarcinogenic Agents
- Azo Compounds
- Carcinogens
- Colonic Neoplasms
- Cytochrome P-450 CYP2E1 Inhibitors
- Drug Synergism
- Enzyme Inhibitors
- Genes, ras
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Precancerous Conditions
- Rats
- Rats, Inbred F344
- Sulfides