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Article

Diallyl sulfide enhances azoxymethane-induced preneoplasia in Fischer 344 rat colon.

Chemico-biological interactions - 1 Feb 2000

Delker D A, Papanikolaou A, Suhr Y J, Rosenberg D W

Abstract excerpt

Azoxymethane (AOM) is an indirect-acting colon carcinogen that produces a high incidence of precancerous lesions, referred to as aberrant crypt foci (ACF), in rats. This study was undertaken to determine whether high dose gavage administration of the cytochrome P-450 2E1 (CYP2E1) inhibitor and chemopreventive agent, diallyl sulfide, would reduce the incidence and severity of ACF formation in the distal colons of...

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Identifiers

PMID: 10728775
DOI: 10.1016/s0009-2797(99)00145-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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