Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations.

Carcinogenesis - 1 Mar 2003

Yang Kan, Fan Kunhua, Kurihara Naoto, Shinozaki Hiroharu, Rigas Basil, Augenlicht Leonard, Kopelovich Levy, Edelmann Winfried, Kucherlapati Raju, Lipkin Martin

Abstract excerpt

Sulindac and other NSAIDs have been widely studied as potential chemopreventive agents for colon cancer. Short-term studies have shown adenomatous polyps to regress in patients with familial adenomatous polyposis (FAP). In this study the effect of sulindac on cancer as an endpoint was evaluated in ApcMin mice, a preclinical model of FAP with an Apc mutation in codon 850 that leads to gastrointestinal adenomas and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to bcl-2-Associated X Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, APC

Share to Intestinal Neoplasms

Share to Intestine, Small

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 12663524
DOI: 10.1093/carcin/24.3.605

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations.PMID 12663524Read ↗

Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.Semantic proximity Read ↗

Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?Semantic proximity Read ↗

Chemoprevention of intestinal adenomas in the ApcMin mouse by piroxicam: kinetics, strain effects and resistance to chemosuppression.Semantic proximity Read ↗

Relationship between APC genotype, polyp distribution, and oral sulindac treatment in the colon and rectum of patients with familial adenomatous polyposis.Semantic proximity Read ↗

Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac.Semantic proximity Read ↗

Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice.Semantic proximity Read ↗

Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP).Semantic proximity Read ↗

Piroxicam increases colon tumorigenesis and promotes apoptosis in Mlh1 +/- /Apc1638(N/+) mice.Semantic proximity Read ↗

Suppression of Familial Adenomatous Polyposis by CP-31398, a TP53 Modulator, in <i>APCmin/+</i> MiceSemantic proximity Read ↗

Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC.Semantic proximity Read ↗

p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse.Semantic proximity Read ↗

Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.