Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice.

doi:10.1093/carcin/20.4.635

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Article

Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice.

Carcinogenesis - 1 Apr 1999

McEntee M F, Chiu C H, Whelan J

Abstract excerpt

Non-steroidal anti-inflammatory drugs (NSAIDs) can cause regression of early intestinal tumors and although this is believed to involve cyclooxygenase-2 and apoptosis, the molecular mechanisms remain unclear. Cytoplasmic and nuclear beta-catenin are overexpressed in many of these lesions and Bcl-2, which inhibits apoptosis, may also be elevated during the course of intestinal tumorigenesis. We recently showed...

Topics

Adenoma
Animals
Anti-Inflammatory Agents, Non-Steroidal
Apoptosis
Colonic Neoplasms
Cyclooxygenase 2
Cytoskeletal Proteins
Enzyme Induction
Gene Expression Regulation, Neoplastic
Genes, APC
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Immunoenzyme Techniques

Intestinal Neoplasms

Intestine, Small

Isoenzymes

Lymphocytes

Mice

Source

Open in PubMed

Identifiers

PMID: 10223192
DOI: 10.1093/carcin/20.4.635

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