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Article

Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC.

Annals of the New York Academy of Sciences - 1 Nov 2005

Chang Wen-Chi L, Everley Lynette C, Pfeiffer Gordon R, Cooper Harry S, Barusevicius Alan, Clapper Margie L

Abstract excerpt

Sulindac sulfone (FGN-1, Aptosyn), a metabolite of the nonsteroidal anti-inflammatory drug sulindac, lacks cyclooxygenase inhibitory activity. Although its ability to inhibit tumorigenesis in both carcinogen-treated animals and patients with familial adenomatous polyposis has been attributed to the induction of apoptosis, its complete mechanism of action remains unclear. The purpose of the present study was to...

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Source

Identifiers

PMID: 16382042
DOI: 10.1196/annals.1339.020

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC.PMID 16382042Read ↗

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