Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC.

doi:10.1196/annals.1339.020

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Article

Sulindac sulfone is most effective in modulating beta-catenin-mediated transcription in cells with mutant APC.

Annals of the New York Academy of Sciences - 1 Nov 2005

Chang Wen-Chi L, Everley Lynette C, Pfeiffer Gordon R, Cooper Harry S, Barusevicius Alan, Clapper Margie L

Abstract excerpt

Sulindac sulfone (FGN-1, Aptosyn), a metabolite of the nonsteroidal anti-inflammatory drug sulindac, lacks cyclooxygenase inhibitory activity. Although its ability to inhibit tumorigenesis in both carcinogen-treated animals and patients with familial adenomatous polyposis has been attributed to the induction of apoptosis, its complete mechanism of action remains unclear. The purpose of the present study was to...

Topics

Adenomatous Polyposis Coli Protein
Antineoplastic Agents
Cell Line, Tumor
Colon
Colonic Neoplasms
Cyclin D1
Cyclooxygenase Inhibitors
Humans
Mutation
PPAR gamma
Sulindac
Transcription, Genetic
beta Catenin

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PMID: 16382042
DOI: 10.1196/annals.1339.020

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