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Article

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.

Chemistry & biology - 1 Feb 2000

Wilkinson B, Foster G, Rudd B A, Taylor N L, Blackaby A P, Sidebottom P J, Cooper D J, Dawson M J, Buss A D, Gaisser S, Böhm I U, Rowe C J, Cortés J, Leadlay P F, Staunton J

Abstract excerpt

BACKGROUND: The macrolide antibiotic erythromycin A, like other complex aliphatic polyketides, is synthesised by a bacterial modular polyketide synthase (PKS). Such PKSs, in contrast to other fatty acid and polyketide synthases which work iteratively, contain a separate set or module of enzyme activities for each successive cycle of polyketide chain extension, and the number and type of modules together determine...

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PMID: 10662692
DOI: 10.1016/s1074-5521(00)00076-4

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FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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