Article
Modular organization of genes required for complex polyketide biosynthesis.
Science (New York, N.Y.) - 3 May 1991
Donadio S, Staver M J, McAlpine J B, Swanson S J, Katz L
Abstract excerpt
In Saccharopolyspora erythraea, the genes that govern synthesis of the polyketide portion of the macrolide antibiotic erythromycin are organized in six repeated units that encode fatty acid synthase (FAS)-like activities. Each repeated unit is designated a module, and two modules are contained in...
Topics
- Amino Acid Sequence
- Binding Sites
- Cloning, Molecular
- DNA, Bacterial
- Erythromycin
- Genes, Bacterial
- Gram-Positive Bacteria
- Hydroxylation
- Models, Molecular
- Molecular Sequence Data
- Molecular Structure
- Multienzyme Complexes
- Mutation
- Nucleic Acid Hybridization
- Repetitive Sequences, Nucleic Acid