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Article

Modular organization of genes required for complex polyketide biosynthesis.

Science (New York, N.Y.) - 3 May 1991

Donadio S, Staver M J, McAlpine J B, Swanson S J, Katz L

Abstract excerpt

In Saccharopolyspora erythraea, the genes that govern synthesis of the polyketide portion of the macrolide antibiotic erythromycin are organized in six repeated units that encode fatty acid synthase (FAS)-like activities. Each repeated unit is designated a module, and two modules are contained in a single open reading frame. A model for the synthesis of this complex polyketide is proposed, where each module...

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Source

Identifiers

PMID: 2024119
DOI: 10.1126/science.2024119

Genes

FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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