Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineered biosynthesis of a complete macrolactone in a heterologous host.

Science (New York, N.Y.) - 22 Jul 1994

Kao C M, Katz L, Khosla C

Abstract excerpt

Macrocyclic polyketides have been subjects of great interest in synthetic and biosynthetic chemistry because of their structural complexity and medicinal activities. With expression of the entire 6-deoxyerythronolide B synthase (DEBS) (10,283 amino acids) in a heterologous host, substantial quantities of 6-deoxyerythronolide B (6dEB), the aglycone of the macrolide antibiotic erythromycin, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Genes, Bacterial

Share to Molecular Sequence Data

Share to Mutation

Share to Recombinant Proteins

Source

Identifiers

PMID: 8036492
DOI: 10.1126/science.8036492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineered biosynthesis of a complete macrolactone in a heterologous host.PMID 8036492Read ↗

A multiplasmid approach to preparing large libraries of polyketides.Semantic proximity Read ↗

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase.Semantic proximity Read ↗

Precursor-directed biosynthesis of 12-ethyl erythromycin.Semantic proximity Read ↗

Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli.Semantic proximity Read ↗

Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins.Semantic proximity Read ↗

Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1.Semantic proximity Read ↗

Isolation and characterisation of amphotericin B analogues and truncated polyketide intermediates produced by genetic engineering of Streptomyces nodosusSemantic proximity Read ↗

Designed Biosynthesis of 36-Methyl-FK506 by Polyketide Precursor Pathway EngineeringSemantic proximity Read ↗

Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strainSemantic proximity Read ↗

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.Semantic proximity Read ↗

Biosynthesis of polyketides (other than actinomycete macrolides)Semantic proximity Read ↗

Precursor Directed Biosynthesis of an Orthogonally Functional Erythromycin Analogue: Selectivity in the Ribosome Macrolide Binding PocketSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.