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Article

Precursor-directed biosynthesis of 12-ethyl erythromycin.

Bioorganic & medicinal chemistry - 1 Aug 1998

Jacobsen J R, Keatinge-Clay A T, Cane D E, Khosla C

Abstract excerpt

A precursor-directed method for the biosynthesis of novel 6-deoxyerythronolide B derivatives has been extended to allow alteration of the functionality at C-12. We recently described a simple and practical method for harnessing the biosynthetic potential of the erythromycin pathway to generate novel molecules of natural product-like complexity by feeding designed synthetic molecules to an engineered mutant strain...

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PMID: 9784859
DOI: 10.1016/s0968-0896(98)00081-9

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