Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strain

18 Jun 2018

Abstract excerpt

BACKGROUND: Polyene antibiotics are important as antifungal medicines albeit with serious side effects such as nephrotoxicity. Reedsmycin (RDM) A (1), produced by marine-derived Streptomyces youssoufiensis OUC6819, is a non-glycosylated polyene macrolide antibiotic with antifungal activity comparable to that of clinically used nystatin. To elucidate its biosynthetic machinery, herein, the rdm biosynthetic gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microbial Natural Products and Biosynthesis
Share to Synthetic Organic Chemistry Methods

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29914489
DOI: 10.1186/s12934-018-0943-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the biosynthetic gene cluster of the polyene macrolide antibiotic reedsmycins from a marine-derived Streptomyces strainPMID 29914489Read ↗

Improved Antifungal Polyene Macrolides via Engineering of the Nystatin Biosynthetic Genes in Streptomyces nourseiSemantic proximity Read ↗

Identification of the Actinomycin D Biosynthetic Pathway from Marine-Derived Streptomyces costaricanus SCSIO ZS0073Semantic proximity Read ↗

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in <i>Streptomyces ambofaciens</i>Semantic proximity Read ↗

Biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces nourseiSemantic proximity Read ↗

Designed Biosynthesis of 36-Methyl-FK506 by Polyketide Precursor Pathway EngineeringSemantic proximity Read ↗

Profile of PKS and NRPS Gene Clusters in the Genome of Streptomyces cellostaticus NBRC 12849TSemantic proximity Read ↗

Identification of a critical gene involved in the biosynthesis of the polyene macrolide lavencidin in Streptomyces lavendulae FRI-5 using the Target-AID (activation-induced cytidine deaminase) base editing technologySemantic proximity Read ↗

Navigating the Fungal Polyketide Chemical Space: From Genes to MoleculesSemantic proximity Read ↗

Oxazolomycin Biosynthesis in Streptomyces albus JA3453 Featuring an “Acyltransferase-less” Type I Polyketide Synthase That Incorporates Two Distinct Extender UnitsSemantic proximity Read ↗

Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan ActinomyceteSemantic proximity Read ↗

Identification and Predictions Regarding the Biosynthesis Pathway of Polyene Macrolides Produced by Streptomyces roseoflavus Men-myco-93-63Semantic proximity Read ↗

Biosynthesis of Polyketides in StreptomycesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.