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Article

Evolution of polyketide synthases in bacteria

4 Feb 2008

Abstract excerpt

The emergence of resistant strains of human pathogens to current antibiotics, along with the demonstrated ability of polyketides as antimicrobial agents, provides strong motivation for understanding how polyketide antibiotics have evolved and diversified in nature. Insights into how bacterial polyketide synthases (PKSs) acquire new metabolic capabilities can guide future laboratory efforts in generating the next...

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PMID: 18250311
DOI: 10.1073/pnas.0710107105

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