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Article

Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1.

Applied and environmental microbiology - 1 Aug 2005

Murli Sumati, MacMillan Karen S, Hu Zhihao, Ashley Gary W, Dong Steven D, Kealey James T, Reeves Christopher D, Kennedy Jonathan

Abstract excerpt

Chemobiosynthesis (J. R. Jacobsen, C. R. Hutchinson, D. E. Cane, and C. Khosla, Science 277:367-369, 1997) is an important route for the production of polyketide analogues and has been used extensively for the production of analogues of 6-deoxyerythronolide B (6-dEB). Here we describe a new route for chemobiosynthesis using a version of 6-deoxyerythronolide B synthase (DEBS) that lacks the loading module. When...

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Identifiers

PMID: 16085842
DOI: 10.1128/AEM.71.8.4503-4509.2005
PMCID: PMC1183267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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