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Article

Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC.

Journal of the American Chemical Society - 30 Jan 2013

Sun Peng, Zhao Qunfei, Yu Futao, Zhang Hua, Wu Zhuhua, Wang Yinyan, Wang Yan, Zhang Qinglin, Liu Wen

Abstract excerpt

Avermectins (AVEs), which are widely used for the treatment of agricultural parasitic diseases, belong to a family of 6,6-spiroketal moiety-containing, macrolide natural products. AVE biosynthesis is known to employ a type I polyketide synthase (PKS) system to assemble the molecular skeleton for further functionalization. It remains unknown how and when spiroketal formation proceeds, particularly regarding the...

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PMID: 23294008
DOI: 10.1021/ja311339u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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