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Article

Designed Biosynthesis of 36-Methyl-FK506 by Polyketide Precursor Pathway Engineering

1 Nov 2012

Abstract excerpt

The polyketide synthase (PKS) biosynthetic code has recently expanded to include a newly recognized group of extender unit substrates derived from α,β-unsaturated acyl-CoA molecules that deliver diverse side chain chemistry to polyketide backbones. Herein we report the identification of a three-gene operon responsible for the biosynthesis of the PKS building block isobutyrylmalonyl-CoA associated with the...

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PMID: 23654255
DOI: 10.1021/sb3001062

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