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Article

Saccharopolyspora erythraea-catalyzed bioconversion of 6-deoxyerythronolide B analogs for production of novel erythromycins.

Journal of biotechnology - 18 Jan 2002

Carreras Christopher, Frykman Scott, Ou Sally, Cadapan Lawrence, Zavala Stefan, Woo Elaine, Leaf Timothy, Carney John, Burlingame Mark, Patel Sajel, Ashley Gary, Licari Peter

Abstract excerpt

A method was developed for the large-scale bioconversion of novel 6-deoxyerythronolide B (6-dEB) analogs into erythromycin analogs. Erythromycin biosynthesis in Saccharopolyspora erythraea proceeds via the formation of a polyketide aglycone, 6-dEB, which is subsequently glycosylated, hydroxylated and methylated to yield the antibiotic erythromycin A. A modular polyketide synthase (PKS) directs 6-dEB synthesis...

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PMID: 11689246
DOI: 10.1016/s0168-1656(01)00372-8

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