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Article

The role of erythromycin C-12 hydroxylase, EryK, as a substitute for PikC hydroxylase in pikromycin biosynthesis.

Bioorganic chemistry - 1 Dec 2004

Lee Sang Kil, Basnet Devi B, Choi Cha Yong, Sohng Jae Kyung, Ahn Jong Seog, Yoon Yeo Joon

Abstract excerpt

The substrate flexibility of the erythromycin C-12 hydroxylase from Saccharopolyspora erythraea, EryK, was investigated to test its potential for the generation of novel polyketide structures. We have shown that EryK can accept the substrates of PikC from Streptomyces venezuelae which is responsi...

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Identifiers

PMID: 15530995
DOI: 10.1016/j.bioorg.2004.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15530995-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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