Article
Influence of nucleotide excision repair and of dose on the types of vermilion mutations induced by diethyl sulfate in postmeiotic male germ cells of Drosophila.
Mutation research - 16 Dec 1999
Sierra L M, Nivard M M, Vogel E W
Abstract excerpt
The role of a defect for nucleotide excision repair (NER) in oocytes on the repair of DNA ethyl adducts induced by diethyl sulfate (DES) in male germ cells of Drosophila was analysed. Frequencies of mutations at multiple loci (recessive lethal mutations) and at the vermilion gene induced in NER+ conditions (cross NER+ x NER+) were compared with those fixed in a NER- background (NER- x NER+). The M(NER-)/M(NER+)...
Topics
- Alkylating Agents
- Animals
- DNA Repair
- Dose-Response Relationship, Drug
- Drosophila
- Drosophila Proteins
- Eye Proteins
- Female
- Genes, Lethal
- Genes, Recessive
- Insect Proteins
- Male
- Meiosis
- Mutagens
- Mutation
- Sequence Analysis, DNA
- Spermatozoa
- Sulfuric Acid Esters