Article
Effect of nucleotide excision repair on ENU-induced mutation in female germ cells of Drosophila melanogaster.
Environmental and molecular mutagenesis - 1 Jan 2003
Alvarez L, Comendador M A, Sierra L M
Abstract excerpt
The role of nucleotide excision repair (NER) in the repair of alkylation damage in the germ cells of higher eukaryotes has been studied mainly by treating postmeiotic male germ cells. Little is known about repair in actively repairing female germ cells. In this study, we treated NER-deficient (ner(-)) mus201(D1) Drosophila females with N-ethyl-N-nitrosourea (ENU) and determined both the mutant frequencies in the...
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