Article
Female germ cell mutagenicity of model chemicals in Drosophila melanogaster: mechanistic information and analysis of repair systems.
Mutation research - 12 Jan 2004
Hernando Julia, Alvarez Lidia, Ferreiro José A, Sancho Ignacio, Comendador Miguel A, Sierra L María
Abstract excerpt
In spite of differences between female and male germ cells, and although both of them contribute to the gene pool of future generations, most germ cell mutagenicity studies in higher eukaryotes have been carried out on males. To study the response of female germ cells to mutagen/carcinogen exposure, the mutagenicity of two model chemicals like diethyl sulfate (DES) and hexamethylphosphoramide (HMPA), and the...
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