Article
N-ethyl-N-nitrosourea predominantly induces mutations at AT base pairs in pre-meiotic germ cells of Drosophila males.
Mutagenesis - 1 Jul 1998
Tosal L, Comendador M A, Sierra L M
Abstract excerpt
Molecular mutation spectra induced by N-ethyl-N-nitrosourea have been obtained in several organisms and test systems, frequently showing different results. In Drosophila melanogaster this spectrum has been analyzed in postmeiotic stages, resulting in good agreement between the adduct spectrum and mutational events, the majority being GC-->AT transitions (61%). However, when collecting data about in vivo...
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