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Article

Molecular analysis of mutations induced in the vermilion gene of Drosophila melanogaster by methyl methanesulfonate.

Genetics - 1 Jul 1992

Nivard M J, Pastink A, Vogel E W

Abstract excerpt

The nature of DNA sequence changes induced by methyl methanesulfonate (MMS) at the vermilion locus of Drosophila melanogaster was determined after exposure of postmeiotic male germ cell stages. MMS is a carcinogen with strong preference for base nitrogen alkylation (s = 0.86). The spectrum of 40 intralocus mutations was dominated by AT----GC transitions (23%), AT----TA transversions (54%) and deletions (14%). The...

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Identifiers

PMID: 1628810
DOI: 10.1093/genetics/131.3.673
PMCID: PMC1205038

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