Molecular analysis of mutations induced in the vermilion gene of Drosophila melanogaster by methyl methanesulfonate.

doi:10.1093/genetics/131.3.673

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Article

Molecular analysis of mutations induced in the vermilion gene of Drosophila melanogaster by methyl methanesulfonate.

Genetics - 1 Jul 1992

Nivard M J, Pastink A, Vogel E W

Abstract excerpt

The nature of DNA sequence changes induced by methyl methanesulfonate (MMS) at the vermilion locus of Drosophila melanogaster was determined after exposure of postmeiotic male germ cell stages. MMS is a carcinogen with strong preference for base nitrogen alkylation (s = 0.86). The spectrum of 40 intralocus mutations was dominated by AT----GC transitions (23%), AT----TA transversions (54%) and deletions (14%). The...

Topics

Animals
Base Sequence
Chromosome Deletion
Crosses, Genetic
DNA Mutational Analysis
Drosophila melanogaster
Ethylnitrosourea
Female
Genes, Lethal
Male
Methyl Methanesulfonate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutagens

Mutation

Reproduction

Spermatozoa

Time Factors

Source

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Identifiers

PMID: 1628810
DOI: 10.1093/genetics/131.3.673
PMCID: PMC1205038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1628810-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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