Article
Comparison of dose-response relationships for ethyl methanesulfonate and 1-ethyl-1-nitrosourea in Drosophila melanogaster spermatozoa.
Mutation research - 1 Jul 1990
Lee W R, Beranek D T, Byrne B J, Tucker A B
Abstract excerpt
The relative importance of different sites of alkylation on DNA was determined by comparing two ethylating agents. 1-Ethyl-1-nitrosourea (ENU) ethylates DNA with a higher proportion of total adducts on ring oxygens than ethyl methanesulfonate, which ethylates with a higher proportion of total add...
Topics
- Animals
- Carbon Radioisotopes
- Crosses, Genetic
- DNA
- Dose-Response Relationship, Drug
- Drosophila melanogaster
- Ethyl Methanesulfonate
- Ethylnitrosourea
- Female
- Male
- Mutagenicity Tests
- Mutation
- Radioisotope Dilution Technique
- Spermatozoa
- Thymidine
- Tritium