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Article

Impact of DNA nucleotide excision repair on methyl methanesulfonate-induced mutations in Drosophila melanogaster.

Carcinogenesis - 1 Aug 1993

Nivard M J, Pastink A, Vogel E W

Abstract excerpt

To study the impact of DNA nucleotide excision repair (NER) on the spectrum of mutations induced by alkylating agents, postmeiotic male germ cell stages of Drosophila melanogaster were exposed to methyl methanesulfonate (MMS) and the males then mated with nucleotide excision repair deficient (exr-; mus(2)201) females. MMS (s value = 0.86) has a strong preference for alkylating the nitrogen positions in DNA,...

Topics

Animals
Apurinic Acid
Base Sequence
Binding Sites
DNA Damage
DNA Repair
DNA-(Apurinic or Apyrimidinic Site) Lyase
Deoxyribonuclease IV (Phage T4-Induced)
Drosophila melanogaster
Endodeoxyribonucleases
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Male

Methyl Methanesulfonate

Molecular Sequence Data

Mutation

Source

Identifiers

PMID: 7689038
DOI: 10.1093/carcin/14.8.1585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7689038-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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