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Article

Impact of DNA nucleotide excision repair on methyl methanesulfonate-induced mutations in Drosophila melanogaster.

Carcinogenesis - 1 Aug 1993

Nivard M J, Pastink A, Vogel E W

Abstract excerpt

To study the impact of DNA nucleotide excision repair (NER) on the spectrum of mutations induced by alkylating agents, postmeiotic male germ cell stages of Drosophila melanogaster were exposed to methyl methanesulfonate (MMS) and the males then mated with nucleotide excision repair deficient (exr-; mus(2)201) females. MMS (s value = 0.86) has a strong preference for alkylating the nitrogen positions in DNA,...

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PMID: 7689038
DOI: 10.1093/carcin/14.8.1585

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