Article
Phenotypes of Drosophila homologs of human XPF and XPG to chemically-induced DNA modifications.
Mutation research - 9 May 2001
Vogel E W, Nivard M J
Abstract excerpt
DmXPF (mei9) and DmXPG (mus201) mutants are Drosophila homologs of the mammalian XPF and XPG genes, respectively. For Drosophila germ cells, causal correlations exist between the magnitude of a potentiating effect of a deficiency in these functions, measured as the M(NER-)/M(NER+) mutability ratio, and the type of DNA modification. M(NER-)/M(NER+) mutability ratios may vary with time interval between DNA adduct...
Topics
- Animals
- DNA Adducts
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Drosophila
- Endonucleases
- Female
- Humans
- Male
- Mice
- Mutagens
- Mutation
- Nuclear Proteins
- Phenotype
- Species Specificity
- Spermatozoa
- Transcription Factors